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Fundamental Health with Paul Saladino, MD

Jul 23, 2019

Dr. Dominic D’Agostino is a tenured Associate Professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC). His laboratory develops and tests nutritional strategies and metabolic-based supplements for neurological disorders, seizures, cancer and metabolic wellness. He was a research investigator and crew member on NASA’s Extreme Environment Mission Operation (NEEMO 22) and has a personal interest in environmental medicine and methods to enhance safety and physiological resilience in extreme environments.  His research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), private organizations and foundations.


Time stamps


5:56 Nasa Neemo 23

17:38 Organization/entrepreneurship/ and prioritization.

19:38 Human Metabolism and the ketogenic diet.

29:07 Glucose Metabolism

31:06 Do we need glucose to run our body?

32:43 What changes in our body when we don't consume carbohydrates.

39:50 Medium chain triglycerides.

42:45 How do we adapt to ketosis?

44:52 Calorie restriction benefits of the ketogenic diet.

48:53 Neuro protective effects of ketones.

49:58 Anti-inflammatory mechanisms of ketones.

53:45 Histone deacetylase 

56:40 Epigenome.

58:00 Krebs Cycle. 

59:51 Mitochondrial Function with Ketones/oxidative stress. 

71:17  Carbohydrate based metabolism and oxidative stress.. 

72:55 Mean amplitude glucose excursions.

76:10  Glucose, inflammation , oxidative stress and insulin resistance.

77:20 The Warburg Effect

89:35 Mitochondria Damage or nucleus damage in regards to cancer.

92:37 Ketogenic diet and Mitochondria protection.

94:20 The most radical thing Dom has done recently.

95:45 Where to find Dom online/upcoming projects. 

Dom’s info:

Instagram: dominic.dagostino.kt

Twitter: DominicDAgosti2


Ancestral Supplements use the promo code “SaladinoMD” on the shopify site for 10% off. 




My contact information:




Instagram: @paulsaladinomd



Facebook: Paul Saladino MD



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